Here's the objection I would make:

I object to the witness assessing the strength of the defense case. It is a legal opinion.

Although the objection should be sustained, assume it is overruled and the testimony continues:

V: No, the Defense is wrong.

G: Are you sure?

V: I'm positive.

G: How could you be so sure?

V: Because there is no way that these tire marks were made by a 1964 Buick Skylark. These marks were made by a 1963 Pontiac Tempest.

T: Objection your honor, can we clarify to the court whether the witness is stating fact or opinion?

THAT WAS A LOUSY OBJECTION BY THE PROSECUTOR. MAKE A BETTER ONE.

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